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Clinical Effects of Ozone Therapy
- Bacteriicidal, Fungicidal, Viricidal, and Anti-Paracitic -
- Ozone had oxidative effect on the microorganisim membrane which contains lipid bio-layer in it's structure and can damage it.
- Therapeutic ozone indirectly activates teh non-specific defense system (activates phagocytosis, enhances synthesis of cytokine-interferons, interleukin tumor-necrotic factor) as well as components of cellular and humeral immunity.
- Causes partial oxidation of virus receptors that make them incapable of binding to the tissue cell.
2. Anti-Inflammatory Effects
- Ozone oxidized the components containing double bonds in their chemical structure, pro-inflammatory arachidonic acid, and its derivatives prostaglandins.
- Ozone regulates metabolic reactions in the inflamed tissue and resolved pH.
3. Analagesic Effect (Pain Reduction)
- Pain reduction takes place due to oxidation of body proteins, albumin (algopeptides)
- Aldopeptides act on nerve endings in the damaged tissue and determine the intensity of pain response
- They have a tendency to decrease molecular toxic by-products which result of lipid peroxidation on cellular membranes.
4. Tissue Detoxification
- Ozone activates metabolic process in the liver kidney tissue, thus insuring their main function of neutralization and elimination of toxic compounds from the body.
5. Activation of Energy Production
- Ozone provides oxygen for oxygen-dependant bio-chemical reaction in the body, aerobic oxidation of carbohydrates, and activation of mitochondria resulting in ATP synthesis (energy production).
6. Optimizing Pro-Oxidative & Anti-Oxidative Systems in the body
- Ozone increases oxidative process causing the compensatory increase in the activity of antioxidant enzymes SOD (superoxidismutase), catalase, and glutatioperoxidase which leads to activation of non-enzymatic antioxidant system (glutathione, vitamin E, ascorbic acid, etc.) 8The use of supplemental Glutathione, N-acethylcysteine (NAC), Vit E, Vit C is obligatory when high ozone concentrations are used.*
7. Blood Coagulation (clotting)
- High ozone concentration administered externally increases blood clotting properties.
- Low dose intravenous administration decreases thrombocytic and coagulative effects and increases fibrinolytic activity (the break down of fibrin, clot dissolving).
8. Immune-Modulating Effects
- Low dose ozone promotes phagocytosis (the engulfing of microorganisms or other cells and foreign particles by phagocytes, part of our white blood cell count) which stimulates activation of our non-specific defense system through specific cytokines (e.g. evaluation of the body temperature, generation of the acute phase peptides in the liver, etc.)
- Low dose ozone activates cellular and humeral immunity and facilitates and treatment of secondary immune deficiency.
9. Auto-Immune Disease
- Ozone in high concentration inhibits activity of cytokines and eliminates activation of T-helper cells. This effects used in the management of patients with autoimmunity disease (e.g. rheumatoid arthritis, scleroderma, disseminated sclerosis) without administration of pharmaceutical drugs.
10. Anti-Neoplastic (Anticancer) Properties
- Ozone can kill tumors and enhance the effect of different types of anti-tumor drugs (study done by Baylor University in Texas in 1962)
- It stimulates the release of Tumor Necrosis Factor alpha by macrophages.
- Ozone does not display direct cyto-toxic effect on lignant cells
- It decreases lactate in the tissue; this can be interpreted as a direct inhibition of tumor metabolism
- Low dose ozone has proven to increase production of anti-cancer a-interferon.
11. Enhancement of Circulatory System
- Ozone increases 2,3-DP6, resulting in the release of oxygen to the tissue, and decreases the binding capacity of hemoglobin
- Ozone increases oxygen carrying capacity of the red blood cells
- Ozone oxidizes plaque in the arteries, unclogging them and decreases clumping of the red blood cells, increasing flexibility of the arteries
12. Neurodegenerative Disease
- Patients with neurodegerative disease under going ozone therapy must receive oral antioxidant supplementation
13. Degeneration of Petrochemicals
- These chemicals have potential to place a great burden on the immune system. They also worsen and even cause allergies and are detrimental to long-term health.
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